Motif ID: POU5F1_SOX2{dimer}.p2

Z-value: 1.273


Transcription factors associated with POU5F1_SOX2{dimer}.p2:

Gene SymbolEntrez IDGene Name
POU5F1 5460 POU class 5 homeobox 1
SOX2 6657 SRY (sex determining region Y)-box 2

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
SOX2chr3_+_1814297110.533.8e-17Click!
POU5F1chr6_-_311346140.171.3e-02Click!


Activity profile for motif POU5F1_SOX2{dimer}.p2.

activity profile for motif POU5F1_SOX2{dimer}.p2


Sorted Z-values histogram for motif POU5F1_SOX2{dimer}.p2

Sorted Z-values for motif POU5F1_SOX2{dimer}.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of POU5F1_SOX2{dimer}.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr2_-_216241321 59.963 FN1
fibronectin 1
chr12_-_91573264 54.828 NM_133503
 DCN
decorin
chr3_-_195310985 36.676 NM_001647
 APOD
apolipoprotein D
chr1_-_93399531 30.104


chr3_-_195310770 29.956 APOD
apolipoprotein D
chr6_-_108145507 26.818 NM_198081
 SCML4
sex comb on midleg-like 4 (Drosophila)
chr3_+_133494275 24.535 TF
transferrin
chr6_+_32407618 17.328 NM_019111
 HLA-DRA
major histocompatibility complex, class II, DR alpha
chr2_-_175712276 16.957 NM_001206602
 CHN1
chimerin (chimaerin) 1
chr10_+_5005685 16.626 AKR1C1
aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase)
chr16_-_55867016 15.790 NM_001025194
NM_001025195
NM_001266
 CES1


carboxylesterase 1


chr10_+_7745284 15.033 ITIH2
inter-alpha-trypsin inhibitor heavy chain 2
chr10_+_7745229 15.009 NM_002216
 ITIH2
inter-alpha-trypsin inhibitor heavy chain 2
chr14_-_106733392 14.492 IGHG1
IGHG3
immunoglobulin heavy constant gamma 1 (G1m marker)
immunoglobulin heavy constant gamma 3 (G3m marker)
chr10_+_5005601 13.966 AKR1C1
AKR1C3
aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase)
aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II)
chr6_-_32497925 13.757 NM_002125
 HLA-DRB5
major histocompatibility complex, class II, DR beta 5
chr10_+_7745325 13.332 ITIH2
inter-alpha-trypsin inhibitor heavy chain 2
chr3_-_9920633 12.940 NM_022094
 CIDEC
cell death-inducing DFFA-like effector c
chr16_-_21314371 12.821 NM_001014444
NM_001888
 CRYM

crystallin, mu

chr10_+_7745354 12.504 ITIH2
inter-alpha-trypsin inhibitor heavy chain 2

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 41 entries
enrichment   p-value GO term description
15.73 1.34e-02 GO:0010660 regulation of muscle cell apoptosis
9.23 2.62e-03 GO:0060338 regulation of type I interferon-mediated signaling pathway
8.42 1.35e-03 GO:0008206 bile acid metabolic process
7.60 3.44e-03 GO:0031214 biomineral tissue development
6.24 2.04e-03 GO:0001959 regulation of cytokine-mediated signaling pathway
6.14 2.42e-03 GO:0060759 regulation of response to cytokine stimulus
5.99 2.72e-02 GO:0006109 regulation of carbohydrate metabolic process
5.99 2.72e-02 GO:0010675 regulation of cellular carbohydrate metabolic process
5.58 1.77e-02 GO:0060337 type I interferon-mediated signaling pathway
5.58 1.77e-02 GO:0071357 cellular response to type I interferon
5.49 2.05e-02 GO:0034340 response to type I interferon
4.07 8.01e-04 GO:0009615 response to virus
3.70 4.52e-02 GO:0007156 homophilic cell adhesion
3.32 2.79e-03 GO:0008202 steroid metabolic process
2.93 4.51e-04 GO:0045087 innate immune response
2.85 2.79e-09 GO:0006955 immune response
2.74 1.15e-03 GO:0051707 response to other organism
2.73 3.75e-02 GO:0016337 cell-cell adhesion
2.71 2.79e-02 GO:0032787 monocarboxylic acid metabolic process
2.50 8.42e-04 GO:0007186 G-protein coupled receptor protein signaling pathway

Gene overrepresentation in compartment category:

Showing 1 to 14 of 14 entries
enrichment   p-value GO term description
2.93 3.60e-12 GO:0005615 extracellular space
2.68 9.04e-13 GO:0044421 extracellular region part
2.37 1.50e-02 GO:0009986 cell surface
2.24 7.36e-09 GO:0005887 integral to plasma membrane
2.20 1.78e-08 GO:0031226 intrinsic to plasma membrane
2.16 3.56e-14 GO:0005576 extracellular region
1.90 1.25e-02 GO:0005624 membrane fraction
1.89 4.33e-09 GO:0044459 plasma membrane part
1.89 1.24e-02 GO:0005626 insoluble fraction
1.62 2.01e-10 GO:0005886 plasma membrane
1.61 3.79e-10 GO:0071944 cell periphery
1.27 1.77e-02 GO:0031224 intrinsic to membrane
1.23 4.01e-02 GO:0044425 membrane part
1.21 1.87e-02 GO:0016020 membrane

Gene overrepresentation in function category:

Showing 1 to 16 of 16 entries
enrichment   p-value GO term description
25.96 3.53e-02 GO:0047023 androsterone dehydrogenase activity
25.96 3.53e-02 GO:0047115 trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity
17.30 1.66e-02 GO:0005132 interferon-alpha/beta receptor binding
6.92 5.95e-03 GO:0003823 antigen binding
4.37 1.47e-03 GO:0008201 heparin binding
4.14 6.71e-05 GO:0001871 pattern binding
4.14 6.71e-05 GO:0030247 polysaccharide binding
3.57 3.54e-04 GO:0005125 cytokine activity
3.53 9.10e-03 GO:0005539 glycosaminoglycan binding
3.08 2.68e-02 GO:0005126 cytokine receptor binding
2.66 1.11e-03 GO:0030246 carbohydrate binding
1.89 3.18e-03 GO:0005102 receptor binding
1.87 3.58e-04 GO:0004888 transmembrane receptor activity
1.82 2.10e-05 GO:0004872 receptor activity
1.72 2.42e-05 GO:0004871 signal transducer activity
1.72 2.42e-05 GO:0060089 molecular transducer activity